Edward McDonnell graduated from the U.S. Naval Academy at Annapolis, Class of 1912. His son, Lieutenant Edward Orrick McDonnell was killed in action as pilot of a P-40 fighter in the U.S. Army Air Forces during World War II. McDonnell retired from the Navy as a Vice Admiral. After his retirement he was killed in the crash of a commercial airliner at Bolivia, South Carolina, on 31 January 1960.